Supplement S4: Casp3-induced Degradation of XIAP Does not Result in Bistability
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چکیده
Experimental evidence suggests that Casp3 activation may result in XIAP cleavage and/or degradation, although this seems to be a cell-type-specific phenomenon (see Discussion). In the following, we demonstrate that Casp3-induced XIAP degradation (‘inhibition of inhibition’ = positive circuit) does not result in physiologically relevant bistability in the absence of other feedback amplification loops.
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